Effect of eliminating CD4-count thresholds on HIV treatment initiation in South Africa: an empirical modelling study

By  Jacob Bor  Shahira Ahmed  Matthew Fox  Sydney Rosen  Dr Gesine Meyer-Rath  Ingrid T Katz, Frank Tanser, Deenan Pillay, Till Barnighausen  |  | 

Bor PLoS One CD4 thresholds and initiationThe World Health Organization recommends initiating antiretroviral therapy (ART) regardless of CD4 count. We assessed the effect of ART eligibility on treatment uptake and simulated the impact of WHO’s recommendations in South Africa. We concluded that removing CD4 criteria alone will modestly increase timely uptake of ART. However, our¬†results suggest the majority of newly-eligible patients will not initiate. Improved testing, linkage,¬†and initiation procedures are needed to achieve 90-90-90 targets.

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PLoS One