TB sequel: incidence, pathogenesis and risk factors of long-term medical and social sequelae of pulmonary TB – a study protocol

By Andrea Rachow, Olena Ivanova , Robert Wallis, Salome Charalambous, Ilesh Jani, Nilesh Bhatt, Beate Kampmann, Jayne Sutherland, Nyanda E. Ntinginya  Denise Evans  Knut Lönnroth, Stefan Niemann, Ulrich E. Schaible, Christof Geldmacher  Professor Ian Sanne  Knut Lönnroth, Stefan Niemann, Ulrich E. Schaible, Christof Geldmacher  |  | 

Up to fifty percent of microbiologically cured tuberculosis (TB) patients may be left with permanent, moderate or severe pulmonary function impairment. Very few studies have systematically examined pulmonary outcomes in patients to understand the pathophysiologic basis and long-term socio-economic consequences of this injury. The planned multi-country, multi-centre observational TB cohort study, aims to advance the understanding of the clinical, microbiological, immunological and socio-economic risk factors affecting long-term outcome of pulmonary TB. It will also determine the occurrence of reversible and irreversible socio-economic consequences t patients, their households and the health sector related to pulmonary TB disease and its treatment.

Publication details

BMC Pulmonary Medicine