THE SLATE ALGORITHM FOR SAME-DAY HIV TREATMENT INITIATION: RESULTS OF THE SLATE TRIAL IN SOUTH AFRICA AND KENYA

By  Sydney Rosen  Dr Mhairi Maskew  Alana Brennan  Lungisile Vezi  Bruce Larson  Tsikhutsu I, Bii M, Venter WDF  |  | 

The World Health Organization recommends “sameday” initiation of antiretroviral therapy (ART) for HIV patients eligible and ready1. This recommendation has been adopted by both South Africa2 and Kenya3. Identifying efficient, safe, and feasible procedures for determining same-day eligibility and readiness is now a priority. The WHO guidelines cited evidence from clinical trials suggesting that offering treatment to
patients at their first clinical encounter has the potential to increase relative uptake of ART within 90 days by 30% and from observational studies that showed an overall relative increase of 53%. All of the trials cited by the WHO, however, relied on access to point-of-care (POC) laboratory instruments, which are not feasible in most routine care settings.

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