Given Malete

Given Malete is no longer working for HE2RO


  • Non-Communicable Diseases

    The past two decades have brought a number of serious threats to public health in South Africa. One of these is the growing burden of non-communicable, chronic diseases. These diseases are already responsible for a large share of premature adult mortality and morbidity, and the burden they impose on the public sector health care system and national health budget is likely to grow substantially in coming years. HE2RO and its partner, Boston University, are developing a body of work to quantify 
  • Rewards for TB Contact Screening (RECON)

    Because of the high risk of both TB and HIV among the household contacts of TB patients and the importance of early case detection for both diseases and especially for DR-TB, improving TB case finding is a high priority. Recent studies have shown that having healthcare workers make multiple visits to the homes of TB patients in order to screen household contacts is a logistically challenging and resource- intensive strategy, and it is not routinely undertaken in most public sector settings in 
  • Rapid Initiation of Antiretroviral Treatment (RapIT) for Pregnant Women

    Alongside the primary RapIT study, we are enrolling pregnant women at a public clinic in Johannesburg in a prospective study of the impact of the guidelines on retention on ART for the duration of pregnancy. We are comparing our main outcome, adherence to ART until delivery, for these women to a retrospective comparison group who received PMTCT under earlier 
  • RapIT: Rapid Initiation of Antiretroviral Therapy to Promote Early HIV/AIDS Treatment in South Africa

    The RapIT study was a randomized strategy evaluation of the feasibility, effectiveness, and cost-effectiveness of rapid ART initiation using accelerated clinic procedures and point-of-care laboratory tests. Outpatient, non-pregnant, HIV-positive adults who came to two South African clinics for an HIV test or CD4 count, consented to study participation, and were eligible for ART under 2010 guidelines were randomized 1:1 to rapid ART initiation or to standard care. Those who were assigned to 
  • Adult Treatment Outcomes and Opportunistic Infections

    As the HIV epidemic matured in South Africa and the national treatment programme reached 10 years since inception, the team at HE2RO has used longitudinal patient databases to evaluate treatment outcomes among adults initiating ART. We consider diverse factors that may influence the effect of ART and also the impact of changing national guidelines in an on-going 
  • RapIT-NCD: Prevalence of NCD risks and conditions in patients on ART

    South Africa, like many other middle income countries, faces very high rates of NCDs and NCD risks but there are virtually no studies looking at NDCs in ART patients and none that have considered the effect of NCDs and NCD risk factors on long term retention on ART. RapIT-NCD is estimating the prevalence of NCDs and NCD risk factors in patients who are stable on ART and examining associations between NCDs and ART outcomes, including mortality, loss to follow up, viral suppression and