Evaluations to Inform Decisions using Economics and Epidemiology (EVIDENCE)

Research Themes: Linkage, Retention and Adherence for HIV Treatment in South Africa Tuberculosis and HIV in South Africa Cost and Budget Modelling Costs, Cost-Effectiveness and Benefits of HIV Care and Treatment HIV Treatment Outcomes and Guidelines

EVIDENCE (Evaluations to Inform Decisions using Economics and Epidemiology) is a 5-year HIV/AIDS Economic Research activity funded by the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR) through a Co-operative Agreement between the United States Agency for International Development (USAID) South Africa and the Health Economics and Epidemiology Research Office (HE2RO). The overall purpose of EVIDENCE is to conduct health economics and epidemiology research to guide evidence-based policy change in support of the goals of the South African National Strategic Plan for HIV, TB and STI’s 2017-2022 (NSP) and the PEPFAR Country Operational Plans 2018-2022.

The EVIDENCE framework identifies four technical focus areas for cost and budget modeling, effectiveness and cost analysis in HIV and TB care and treatment service delivery programs and innovative models for prioritizing healthcare resources.

In each focus area, a set of integrated activities is proposed, aimed at providing policy-relevant information on the key questions facing policy makers in that area. Methodological approaches to be used for this work include cost, outcome, and cost-effectiveness analysis; impact, cost, and budget modeling; program evaluation to inform planning and targeting of resources; leveraging of existing data sources; and focus on priority districts and key and vulnerable populations. Results generated by EVIDENCE will provide information to help guide decisions about program efficiency, guideline changes, models of service delivery, budgeting and resource allocation, and quality.

EVIDENCE builds on substantial knowledge, skills, relationships, and accomplishments over 15 years by the HE2RO team and partners under the INROADS Innovation Activity, prior cooperative agreements with USAID, and projects supported by other funders. Sub-awards on the EVIDENCE program include the Department of Global Health, Boston University (a long-standing collaboration since 2004) and the Centre for Economic Governance and Accountability in Africa (CEGAA).

Funded by


  • National COVID-19 Model and Budget reports – Estimating cases for COVID-19 for South Africa

    We are pleased to announce that we are now able to share the reports on the projections of the National Covid-19 Epi Model to which a number of HE2ROs have contributed. The long-term national and provincial reports are available here. They will be updated about once a month. Over the last eight weeks, Gesine Meyer-Rath, Lise Jamieson, Brooke Nichols, Jacqui Miot and Kerensa Govender have been working with the National Department of Health (NDoH) and National Treasury to aid decision making 


HE2RO staff involved

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