Evaluations to Inform Decisions using Economics and Epidemiology (EVIDENCE)

Research Themes: Linkage, Retention and Adherence for HIV Treatment in South Africa Tuberculosis and HIV in South Africa Cost and Budget Modelling Costs, Cost-Effectiveness and Benefits of HIV Care and Treatment HIV Treatment Outcomes and Guidelines

EVIDENCE (EValuations to Inform Decisions using EcoNomiCs and Epidemiology) is a program of technical assistance, evaluation, including health financing, cost and cost effectiveness analysis, cost modelling, and implementation analysis, aimed at assisting the Government of South Africa (GoSA) to achieve the goals of its National Strategic Plan on HIV, TB and STIs 2023-2028 (NSP) (1), national and international 95-95-95 targets (2), and PEPFAR COP 23 objectives (3). EVIDENCE has been running for 5 years under a cooperative agreement with USAID and has been integral in contributing to HIV and TB policy development and decision-making and has embarked on its Year 6 Workplan.

The overall purpose of EVIDENCE Y6 is to conduct health economics, health finance and epidemiology research and evaluation to guide evidence-based policy change in support of the goals of the South African NSP for HIV, TB and STI’s and the PEPFAR COP. Activities are designed to generate strategic information across the HIV care cascade. This information will be used to inform budget modelling and investment strategies for the mobilization of resources necessary to sustain the current HIV program and reach South Africa’s targets.

In line with the COP23 objectives for South Africa, the program of activities for FY24 (6 Focus Areas) emphasizes technical assistance and evaluation in direct support of the GoSA in achieving the proposed COP23 benchmarks.

In each Focus Area, a set of integrated activities is proposed, aimed at providing policy-relevant information on the key questions facing policy makers in that area. Methodological approaches to be used for this work include cost, outcome, and cost-effectiveness analysis; impact, cost, and budget modelling; program evaluation to inform planning and targeting of resources and leveraging of existing data sources.

EVIDENCE Y6 builds on substantial knowledge, skills, relationships, and accomplishments over 20 years by the HE2RO team and partners under the INROADS Innovation Activity, EVIDENCE 5 year activities, prior cooperative agreements with USAID, and projects supported by other funders. Sub-awards on the EVIDENCE Y6 program include the Department of Global Health, Boston University (a long-standing collaboration since 2004) and the Centre for Economic Governance and Accountability in Africa (CEGAA).

Funded by


  • National COVID-19 Model and Budget reports – Estimating cases for COVID-19 for South Africa

    We are pleased to announce that we are now able to share the reports on the projections of the National Covid-19 Epi Model to which a number of HE2ROs have contributed. The long-term national and provincial reports are available here. They will be updated about once a month. Over the last eight weeks, Gesine Meyer-Rath, Lise Jamieson, Brooke Nichols, Jacqui Miot and Kerensa Govender have been working with the National Department of Health (NDoH) and National Treasury to aid decision making 


HE2RO staff involved

Stay up to date

Receive newsletters and keep up to date with developments at HE2RO.