Growth curve modelling to determine distinct BMI trajectory groups in HIV-positive adults on antiretroviral therapy in South Africa

By  Dr. Alana Brennan  Kaitlyn M. Berrya  Professor Sydney Rosen  Andrew Stokes, Nigel J. Crowther, Jaya George, Frederick Raal, Naseem Cassim,  Dr. Lawrence Long  Dr. Matthew Fox  |  | 

Objective: Obesity is a major long-term concern in HIV-positive patients due to the pathogenic link between obesity and noncommunicable chronic diseases (NCDs). We aim to characterize changes in BMI over time on antiretroviral therapy (ART) and investigate the association between weight gain and survival in South Africa.
Design and methods: A prospective cohort study among HIV-positive adults on first-line ART between April 2004 and 2015 in Johannesburg, South Africa. We used latent class growth modeling (adjusted for age, sex and CD4รพ cell count) to identify groups of individuals with similar patterns of change in BMI over time.

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