Immune Recovery After Starting ART in HIV Infected Patients Presenting and Not Presenting With Tuberculosis in South Africa

By Michael Schomaker  Matthias Egger  Dr Mhairi Maskew  Daniela Garone  Hans Prozesky  Christopher J. Hoffman  Andrew Boulle  Lukas Fenner  |  | 


We studied the immune response after starting antiretroviral treatment (ART) in 15,646 HIV-infected patients with or without tuberculosis (TB) at presentation in 3 ART programs in South Africa between 2003 and 2010. Patients presenting with TB had similar increases in CD4 cells compared with all other patients (adjusted difference 4.9 cells/┬ÁL per 6 months, 95% confidence interval: 0.2 to 9.7). Younger age, advanced clinical stage, female sex, and lower CD4 cell count at ART start were all associated with steeper CD4 slopes. In South Africa, HIV-infected patients presenting with TB experience immune recovery after starting ART that is no worse than in other patients.



Publication details

Journal of Acquired Immune Deficiency Syndromes