Implementation of Option B and a fixed-dose combination antiretroviral regimen for prevention of mother-to-child transmission of HIV in South Africa: A model of uptake and adherence to care

By  Dr Mhairi Maskew  Lise Jamieson  Given Malete  Lawrence Long  Constance Mongwenyana  Cynthia Nyoni  Dorah Mokaba  Matthew Fox  Professor Ian Sanne  Sydney Rosen  |  | 

Initiating and retaining pregnant women on antiretroviral therapy (ART) to prevent motherto-child HIV transmission (PMTCT) remains a major challenge facing African HIV programs, particularly during the critical final months prior to delivery. In 2013, South Africa implemented
its ªOption Bº PMTCT regimen (three-drug ART throughout pregnancy andbreastfeeding, regardless of maternal CD4 count) and introduced once-daily fixed-dose combinations and lifelong ART. Currently, the uptake of Option B and its possible impact on adherence to PMTCT during the critical final months of pregnancy is unclear.

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