In 2014, the National Department of Health (NDOH) drafted a strategy to improve adherence to chronic disease medication in South Africa. The strategy includes adherence to HIV, TB, non-communicable disease, and mental health medications. Before the strategy can be adopted, estimates of its overall resource requirements and cost to the national budget are needed. It is also important to estimate the cost of each intervention included in the strategy, so that interventions can be prioritized if insufficient resources are available to implement the entire strategy. In October 2014, the Health Economics and Epidemiology Research Office (HE2RO) was asked tomake these cost estimates. This report contains the preliminary results of our cost analysis, for review and comment by NDOH and other stakeholders. It will be finalized once feedback has been received and incorporated into the analysis and report. This report is based on the 1 December 2014 draft of the adherence guide. The adherence guide contains a stepwise approach to supporting linkage to care, retention in care and adherence to treatment through the continuum of care based on a detailed outline of evidence based models and interventions that support linkage to care, adherence and retention in care. In the implementation plan facilities are provided with a minimum package of interventions to support linkage to care, adherence and retention in care with further optional interventions. The cost estimates provided in this document focus on the minimum package of interventions.