Recent Publications

What will it take for an injectable ARV to change the face of the HIV epidemic in high-prevalence countries? Considerations regarding drug costs and operations

The proven effectiveness of injectable cabotegravir (CAB-LA) is higher than that of any other HIV prevention intervention ever trialled or implemented, surpassing medical male circumcision, condoms and combination antiretroviral treatment. Based on our own analyses and experience with the South African oral pre-exposure prophylaxis (PrEP) programme, we review the supply and demand side factors that would need to be in place for a successful rollout of CAB-LA, and delineate lessons for the 

Jointly Modelling the Epidemiological and Macro-Economic Impact of COVID-19 in South Africa: The Tekanelo Model and Its Role in Planning for the Fourth Wave of COVID-19 Cases in South Africa

In order to support economic decision-making in South Africa, we developed Tekanelo, an epidemiologiceconomic modelling suite incorporating epidemiological model outputs regarding different vaccine and variant scenarios to develop shocks imposed on an existing computable general equilibrium model for South 

Understanding the Costs and Resource Requirements for Offering a Smoking Cessation Programme at Primary Health Care Facilities in South Africa

Background Tobacco dependence associated with an increased risk for developing lung cancer. The health benefits of quitting smoking have been well-established. In South Africa, smoking cessation support is mainly through private support. How much it will cost to make a smoking cessation service available publicly? Guidelines for the continuum of care in lung cancer have been 

Prior exposure to antiretroviral therapy among adult patients presenting for HIV treatment initiation or re-initiation in sub- Saharan Africa: A systematic review

Background and objectives Same-day/rapid ART initiation + high rates of disengagement from care have created a large and growing pool of individuals who present for initiation of treatment with prior ART experience (“non-naïve re-initiators”) By definition, non-naïve re-initiators previously were unable to overcome barriers to care and may face those same barriers again, without tailored interventions There are many estimates but few empirical data on the proportion of 

Adult South African men preferences for HIV pre-exposure prophylaxis (PrEP): A discrete choice experiment comparing long acting injectable versus daily oral tablet

The pending approval of long-acting injectable (LAI) pre-exposureprophylaxis (PrEP) in South Africa (SA) has the potential to significantly change the biomedical HIV prevention space which currently relies heavily on daily, oral PrEP. Prior to the rollout of LAI in SA, it is important to understand what attributes of each modality and its delivery are likely to influence decision making amongst underserved populations such as sexually active adult 

“I didn’t understand well” – COVID-19 vaccine and booster misconceptions among the general population and people living with HIV in South Africa

Overcoming vaccine hesitancy and enhancing vaccine uptake is a critical public health priority. Research on knowledge and beliefs about COVID-19 vaccines in South Africa can be useful for developing messages that utilize behavioural economics (BE) insights and effectively counter misconceptions. Such an approach could also be applied to future HIV vaccine campaigns. 

Nudging men towards voluntary medical male circumcision: A quasi-experimental study in South Africa of four interventions using behavioural economics insights to increase demand for circumcision

While voluntary medical male circumcision (VMMC) has great potential to reduce HIV incidence, demand for VMMC in South Africa is below global and national targets. We evaluated the impact of four online VMMC recruitment forms, designed using behavioural economics insights, on men signing up for VMMC using the data free mobile App, 

Rapid learning to inform behavioural interventions for HIV programmes – Lessons from Indlela’s Behavioural Hub (B-Hub)

Behavioural economics holds enormous potential as a discipline that can suggest cost-effective interventions to address various public health challenges. To realize this potential, we created a Behavioural Hub (B-Hub), a group of individuals (potential clinic attendees, clinic attendees, clinic staff) who consent to provide ongoing feedback on intervention designs, complete rapid surveys, participate in A/B testing of prototypes, and offer contextual input on HIV service delivery