The Cost of the Xpert Diagnostic Algorithm for TB Results of the National TB Cost Model (NTCM) 2011/12 to 2016/17

By  Professor Gesine Meyer-Rath  Dr. Lawrence Long  Dr. William Macleod  Professor Ian Sanne  Professor Sydney Rosen  |  | 

South Africa bears a large share of the global burden of HIV and tuberculosis co-infection. The GeneXpert System (Cepheid) using the Xpert MTB/RIF assay, a cassette-based cartridge, has provided the possibility of a rapid diagnosis of tuberculosis, while simultaneously providing a rapid screen for rifampicin (RIF) resistance. The assay is highly sensitive and specific for M. tuberculosis (MTB) infection and has received a strong recommendation from the World Health Organization (WHO) in December 2010 as the initial test in individuals suspected of MDR-TB or those with HIV co-infection.

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