Understanding mobility patterns in people with drug-resistant tuberculosis in two South African provinces

By Lebogang Ngolele  Natalie Robbins  Lebohang Mlambo  Siya Dubazana  Dr. Denise Evans  Karen Jacobson  Robert Horsburgh  Laura White  Samantha Malatesta  Dr. Ribka Berhanu  |  | 

ABSTRACT
Background/Objectives:
Estimates suggest 84% of tuberculosis (TB) transmission happens outside the home, yet transmission locales remain unclear. We aimed to study geographic mobility patterns among adults with rifampicin-resistant (RR) and multidrug-resistant (MDR) TB for future active case-finding strategies.
Design/Methods:
We recruited individuals diagnosed with RR/MDR-TB in North West and Free State provinces. Using ArcGIS, we mapped homes and commonly frequented locations. Activity-space size was measured as the smallest convex polygon containing all mapped locations. Differences in activity-space were assessed using linear regression, t-test, and Wilcox Rank Sum.

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