Using a Self-Administered Electronic Adherence Questionnaire to Identify Poor Adherence Amongst Adolescents and Young Adults on First-Line Antiretroviral Therapy in Johannesburg, South Africa

By  Kamban Hirasen  Dr. Denise Evans  Nelly Jinga  Rita Grabe; Julia Turner; Sello Mashamaite  Dr. Lawrence Long  Dr. Matthew Fox  |  | 

Introduction: The best method to measure adherence to antiretroviral therapy (ART) in resource-limited settings has not yet been established, particularly among adolescents and young adults (AYAs). The use of mobile technology may address the need for standardized
tools in measuring adherence in this often marginalized population.
Methods: We conducted a cross-sectional validation study among AYAs (18–35 years) attending a South African HIV clinic between 07/2015-09/2017.We determine the diagnostic accuracy of two modes of delivering an adherence questionnaire (self-administered electronic vs interviewer-administered paper-adherence questionnaire) comprising two self-reported adherence tools (South African National Department of Health (NDoH) adherence questionnaire and the Simplified Medication Adherence Questionnaire (SMAQ)) to identify poor adherence compared to; 1)
a detectable viral load (≥1000 copies/mL) and 2) a sub-optimal concentration of efavirenz (EFV) (EFV ≤1.00 μg/mL) measured by therapeutic drug monitoring (TDM).

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